Eloisa Herrera Laboratory
Generation and Regeneration of Bilateral Neural Circuits
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Our laboratory is dedicated to unraveling the molecular mechanisms that regulate axonal navigation
Understanding the principles that govern axon guidance during development may provide key insights for regenerative medicine, offering strategies to restore damaged circuits in the adult CNS
Mission
The precise trajectory of different neuronal types during development is essential for the proper formation of functional circuits. We investigate the molecular and cellular mechanisms underlying axon pathfinding, focusing on how neurons interpret extracellular cues, make directional choices, and integrate into neural networks.
Our research explores the role of intrinsic neuronal factors, transcriptional and epigenetic regulators, and extrinsic signals that shape axonal navigation and define specific neuronal trajectories.A major focus of our work is deciphering how signaling pathways—particularly those involved in cytoskeletal remodeling and axon guidance—contribute to both developmental and regenerative processes.
By bridging developmental neuroscience with regenerative medicine, we aim to develop innovative therapeutic approaches to restore neuronal connectivity in the injured CNS.
Using a combination of in vivo and in vitro models, advanced imaging techniques, and molecular biology tools, we dissect the intricate signaling networks that control axon guidance and circuit assembly. Ultimately, our research seeks to pave the way for future clinical applications that could benefit patients with neurodegenerative diseases or CNS injuries.
OUR HISTORY
Our journey began in 2005 when our laboratory was founded at the Institute of Neurosciences. From the very start, our mission has been to uncover the molecular mechanisms that guide axons as they navigate through the developing nervous system. Understanding this intricate process has fascinated us for years, but our vision extends beyond fundamental research.
Over time, we have increasingly focused on translating our discoveries into regenerative medicine, aiming to harness these mechanisms to repair damaged neural circuits. Our goal is not only to expand scientific knowledge but also to contribute to innovative therapies that could one day restore lost neural connections.
This exciting path has been made possible thanks to the support of prestigious national and international funding agencies, including the European Research Council (ERC), La Caixa, the Prometeo Program of the Generalitat Valenciana, the Human Frontiers Science Program, the Spanish Ministry of Science, the Ramón Areces Foundation, the Tatiana Foundation, La Marató, and many others.