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New paper in Cell Reports

Our paper "The Ciliary Margin Zone of the Mammalian RetinaGenerates Retinal Ganglion Cells" has just been published in Cell Reports (2015 Impact Factor 7,870) in collaboration with Dr. Carol Mason's group from Columbia University (New York, USA).

The article explains that the retina of lower vertebrates grows continuously by integrating new neurons generated from progenitors in the ciliary margin zone (CMZ). Whether the mammalian CMZ provides the neural retina with retinal cells is controversial. Live imaging of embryonic retina expressing eGFP in the CMZ shows that cells migrate laterally from the CMZ to the neural retina where differentiated retinal ganglion cells(RGCs) reside. Because Cyclin D2, a cell-cycle regulator, is enriched in ventral CMZ, we analyzed CyclinD2/ mice to test whether the CMZ is a source of retinal cells. Neurogenesis is diminished in CyclinD2 mutants, leading to a reduction of RGCs in the ventral retina. In line with these findings, in the albino retina, the decreased production of ipsilateral RGCsis correlated with fewer Cyclin D2+ cells. Together, these results implicate the mammalian CMZ as aneurogenic site that produces RGCs and whose proper generation depends on Cyclin D2 activity.


Click here for read the full article.


In the first pic Dr. Carol Mason and Dr. Florencia Marcucci, co-first author of the paper.

In the second pic Dr. Verónica Murcia, co-first author of the paper, Dr. Eloísa Herrera and Yaiza Coca.

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